Interferon – a part of the immune system

The role of interferons in the evolution of vertebrates

Interferons (IFN) are the basis of antiviral protection in all vertebrates.

When attacked by viral particles, almost any cell in the body can synthesize interferon molecules, informing the rest of the cells that it is infected. Immune cells move towards this signal to eliminate the danger faster. Tissue cells, having received the IFN signal, rearrange their biochemical processes to protect themselves from viruses or slow down their reproduction if they failed to protect themselves.

Innate immunity is a quick but crude response to danger. The innate immune system triggers the acquired immune system through the interferon system – an exact but slow tool for protecting the body from external influences.

The IFN molecule does not fight directly against the viral particle but triggers all the antiviral protection mechanisms without exception. [Read more…]

Interferon triggers all the antiviral protection mechanisms

Actual knowledge about human interferon

Interferon in the human body is produced and functions based on the same principles as in other vertebrates. The human IFN system’s peculiarity is the variety of protective and regulatory processes triggered or stimulated by interferon. Depending on which genes encode the form of the IFN molecule, there are 3 types of interferon.

People have been using interferon since 1960 for the prevention and treatment of viral, fungal, and oncological diseases. [Read more…]

n 2020, the study of human interferon was mainly aimed at combating the COVID-19 pandemic. Some current topics:

Interferon Prevents Coronavirus Cytokine Storm in Diabetic Patients

Interferon increases levels of the enzyme SETDB2, which suppresses inflammation

Interferon Autoantibodies Increase The Risk of Critical COVID-19 in Elders

Autoantibodies that neutralize type I interferons are present in 4% of uninfected people over 70 and are responsible for 20% of deaths from COVID-19

Interferon-α2b inhalation improves clinical outcomes in COVID-19 patients

The timing of treatment initiation is crucial – up to 5 days from the onset of symptoms

Interferons against diseases

Interferons are highly active molecules with strictly regulated synthesis by different body systems. To survive, some pathogens are able to counteract the production and action of interferons. Humanity has learned to produce additional IFN molecules to treat and prevent disease.

This section talks about research on diseases against which interferons are effective.

Роль интерферона-гамма в болезни Паркинсона

T-клетки способствуют воспалению и гибели дофаминергических нейронов

Cause of Mental Disorders in COVID-19

Inflammatory proteins disrupt hippocampal neurogenesis

Ways to Overcome Chronic Fatigue after COVID-19

Post-Covid Syndrome Treatment: Vagus Nerve Stimulation

Longevity and interferons: general factors for a healthy life

Interferons are part of the innate immune system. It is the immune system that provides homeostasis – the body’s ability to maintain its vital functions. The better the immune system works, the longer the body lives.

Many health factors are aimed at strengthening the immune system and hence the interferon system. This section presents studies that identify and explain the “longevity – immunity – interferon” relationship.

Coffee for Asthma

Caffeine short-term improves lung function

Exercise or Metformin: Which is Better for Insulin Resistance?

A combination of aerobic and strength training improves fat oxidation and insulin sensitivity

Daily Vegetable Consumption Reduces The Risk of Dementia In Elders

400 grams of vegetables reduce the risk of dementia by 31%

Nutrition to Protect DNA: What Foods Slow Down The Aging

Effect of food, nutrients, and dietary habits on telomere length

How Alcohol Reduces Volume and Cognitive Functions of The Brain

A series of multi-year studies

Three Eggs A Day Protect Against Cardiovascular Disease

Eating Eggs Improves Cholesterol Clearance and Reduces Oxidative Stress