Diseases
Тяжелый COVID-19 сопровождается реактивацией хронических вирусных инфекций
Реактивация анелловирусов связана с развитием длительного COVID
Назальный иммунитет при респираторных вирусных инфекциях
Сила и продолжительность ответа интерферонов определяет защиту от вирусов
Type I Interferons Help Macrophages Prevent Severe Lung Damage During Coronavirus Infection
Nerve- and Airway-Associated Macrophages Are Essential for a Favorable Outcome of SARS-CoV-2 Infection
Severe Respiratory Infections Increase the Risk of Lung Cancer
Vaccination May Reduce the Long-Term Consequences of Viral Infections
Interferons Help the Thymus Prevent Autoimmune Responses
T Cells Learn Not to Attack Self-Tissues Even During Inflammation
Type I Interferon-Based Gene Therapy for Glioblastoma
Phase 1/2a Clinical Trial Results
Aging and Vaccination: Why Age Requires New Approaches
Which vaccines work best?
Type I Interferons Support CD8 T Cells During Chronic Infection
High antigen load increases T-cell dependence on B cells
Type I Interferon Responses During Pregnancy May Contribute to Neurodevelopmental Disorders in Offspring
Controlling Type I Interferon Responses and Using Anti-Inflammatory Therapy May Reduce Risk
Cholesterol as a Therapeutic Target in Cancer and Inflammatory Diseases
Cholesterol Metabolism Regulates Immune Function
Autoantibodies May Cause Neurological Symptoms in Long COVID
Autoantibodies Against Nervous System Proteins Identified in Post-COVID Syndrome
Physical Exercise Increases Interferon Production and Enhances Antiviral Immunity
Physical Activity Increases Hepatic 3-HB Production, Promoting Gpld1 Expression and Subsequent Interferon Production
Type I Interferons Enhance Antibody Responses to Influenza Vaccination
The IL-21/IL-12 Pathway Also Enhances Antibody Production Independently of Type I Interferons
Epstein–Barr Virus–Reactive CD8 T Cells Identified in Patients With Multiple Sclerosis
EBV May Sustain the Expansion of CD8 T Cells in the Central Nervous System
Type I Interferons Regulate Blood Coagulation
Disrupted Type I IFN Signaling Increases the Risk of Thrombosis in COVID-19, Bacterial Sepsis, and Systemic Lupus Erythematosus
Autoantibodies May Contribute to the Development of Long COVID
Transfer of IgG From Long COVID Patients Induces Pain Hypersensitivity in Mice
Interferon Lambda Delays Intestinal Repair After Injury
A Mechanism Impairing Mucosal Healing in Patients With Inflammatory Bowel Disease
Interferon-α2b Gene Therapy for Non-Muscle-Invasive Bladder Cancer
Nadofaragene Firadenovec-vncg – A Safe Alternative to Cystectomy in BCG-Unresponsive Cancer
Scientists Develop Technology for Systemic Analysis of Diseases and Drug Effects
Artificial intelligence trained to recognize tissues and cells in histological images
Hearing Loss in COVID-19 Is Associated with Spiral Ganglion Neuron Death
SARS-CoV-2 Spike Protein Disrupts Autophagy
Biological Clocks Enhance the Brain’s Antiviral Defense
In mice, the type I interferon response to a virus-like stimulus is triggered faster at the onset of darkness
Interferon Lambda: A New Stage in Antiviral Therapy
The efficacy of IFN-λ against hepatitis viruses and SARS-CoV-2
Food Intake Enhances T-Cell Functions
Metabolites Generated After Meals Improve the Effectiveness of Cancer Cell Therapy
Antiprotozoal Therapy and Varicella Vaccination Reduce Alzheimer’s Disease Risk
Effects Do Not Add Up – Each Protective Factor Acts Independently in the Absence of the Other
Type III Interferon Response Determines the Course of Rhinovirus Infection
NLRP1 and IL-1 Are Potential Targets for Reducing Excessive Inflammation
CD4 Memory T Cells in the Nasal Mucosa Provide Cross-Protection Against Influenza A
These Cells Limit Viral Replication and Reduce Tissue Damage
Epstein–Barr Virus as a Risk Factor for Hodgkin Lymphoma
Viral Load Depends on Genetics, Sex, Age, and Smoking
Nasal Interferon-Alpha Prophylaxis May Reduce Asthma Risk in Children
Respiratory Viral Infections Increase Asthma Risk by 59%
Bone Marrow Plasma Cells Are a Source of Autoantibodies to Interferon-Gamma in Adult-Onset Immunodeficiency
Why Rituximab Does Not Eliminate Autoantibodies in AOID
The Role of Type I and Type III Interferons in Protecting the Fetus from Zika Virus
Key Mechanisms of Maternal–Fetal Transmission of Zika Virus
Intranasal Interferon-Alpha Spray Reduces COVID-19 Risk in Cancer Patients
Randomized Double-Blind Placebo-Controlled Trial
Universal Vaccine Induces Immunity Against Respiratory Infections
Protection Duration Exceeds 3 Months
Fever as a Mechanism of Antiviral Defense
The Role of Temperature in the Evolution of Antiviral Genes
Autoantibodies to Interferons Increase the Risk of Severe West Nile Virus Disease
Autoantibodies were detected in 40% of patients with neuroinvasive disease
Glucocorticoid Receptor Helps Tumor Cells Survive Immune Attack
Selective GR Suppression Enhances Immunotherapy And Reduces Metastasis
ISG15 Deficiency Leads To Delayed Wound Healing And Fibrosis
Hyperactivation Of The Interferon Signaling Pathway In ISG15 Deficiency
Inhaled IFN-α2b Accelerates Recovery in Children With Adenoviral Pneumonia
Clinical Symptoms Resolve 17% Faster
How Immune Responses To RSV And SARS-CoV-2 Differ In Infants
Impaired NK Cell Function In Severe RSV
Booster Intranasal Vaccination Enhances Respiratory Tract Immunity
Primary Immunization Is Critical
Blood Immune Cell Profile As An Indicator Of Inflammatory Diseases
An Atlas Of Circulating Immune Cells Refines Disease-Specific Mechanisms Of Inflammation
Type I Interferons Regulate Immune Activation And Inflammation Resolution
Interferons Reprogram Macrophage Metabolism Upon Recognition Of Cytosolic Nucleic Acids
The Cause of Rare Complications After Some COVID-19 Vaccines
Genetic Predisposition Combined With Anti-PF4 Antibody Production Increases the Risk of Thrombosis and Thrombocytopenia
Autoantibodies to Type III Interferons in Cystic Fibrosis
Association of Autoantibodies to IFN-λ2/3 With Allergic Rhinitis and Impaired Antiviral Defense
Antifungal Vaccines: So Necessary, So Feasible, Yet Still So Distant
The Eng2 Antigen as a Basis for a Future Pan-Fungal Vaccine
Type I Interferon Responses Enhance the Regenerative Activity of Salivary Gland Stem Cells After Radiotherapy
Blockade of IFN-β or RIG-I Attenuates This Effect
Antiviral Defense of the Nasal Mucosa Weakens With Age
Prolonged Infection Leads to More Severe Disease
Endogenous Retroelements as Regulators of Oral Tolerance
The cGAS–STING Pathway Is Required for Protection Against Food Allergy
Therapeutic Potential of Type I Interferon in Enhancing Sensitivity to Cancer Immunotherapy
Type I Interferon Regulates Metastasis and Improves Tumor Response to Immune Checkpoint Blockade
Long COVID: Chronic Inflammation and T Cell Dysfunction
JAK–STAT, IL-6, and Interferon Signaling Pathways as Potential Therapeutic Targets
Nasal Interferon Reduces the Period of Infectiousness in Children Infected With Coronavirus
Shortening the Period – Containing the Pandemic
Gut Microbiota as a Regulator of Innate Antiviral Immunity
Intestinal Bacteria Are Required for Basal Activation of the cGAS–STING–IFN-I Axis
Children With Severe Influenza Produce Little Interferon in the Nose
Mild Influenza Is Associated With Much Higher Interferon Levels
Autoantibodies to Interferon Alpha in Patients With Antibody Deficiency
Autoantibodies Are Rare and Do Not Affect Coronavirus Vaccination
Breastfeeding Protects Infants From Severe Influenza by Activating Type I Interferon Production
The Effect Is Observed for Influenza but Not for RSV or Metapneumovirus
Autoantibodies to Type I Interferons Increase the Risk of Fulminant Hepatitis Caused by HSV
Therapeutic Opportunities With Interferons
Autoantibodies to Type I Interferons – A Risk Factor for Fatal Avian Influenza H5N1
A Case of Pneumonia in a 71-Year-Old Man
Early RSV Infection and Familial Allergy Increase the Risk of Asthma
RSV Immunoprophylaxis Prevents Allergic Airway Inflammation in Mice
Vaccine Targeting IgE
IgE-K Induces Neutralizing Antibodies Similar to Omalizumab
Development of a Universal Influenza A Vaccine
Antigen AC–Anhui Provides Broad Immune Protection
PLD4 Mutations as a Genetic Cause of Systemic Lupus Erythematosus
PLD4 Deficiency Leads to Excessive Activation of the Type I Interferon Pathway
Nasal Interferon Restores the Nasal Immune Landscape During Viral Infection
Type I Interferon Accelerates Clearance of Metapneumovirus
Infections as a Key Factor in Prematurity and Infant Mortality
The Importance of Preventing ARVI and STIs in Reducing the Risk of Placental Pathology
Prevention of ARVI in Pregnant Women and Newborns: Evaluating the Efficacy and Safety of Intranasal Interferon
Intranasal Interferon α-2b Prevents ARVI and Mitigates Disease Severity
Type I Interferons Are Essential for Early Control of Candida albicans in Vulvovaginal Candidiasis
Absence of IFN-I Signaling Increases Fungal Burden and Inflammation
How the Immune System Responds to Tuberculosis: The Role of Type I Interferons, Neutrophils and T Cells
Early Immune Mechanisms That Determine the Outcome of Mycobacterium Tuberculosis Infection
Seven Puzzles of Coronavirus
Pneumonia, MIS-C, Neuro-COVID, COVID Toes, Post-COVID Syndrome, Resistance to Infection, and Adverse Reactions to mRNA Vaccines
Pregnancy and Breastfeeding Protect Against Breast Cancer
CD8+ T Cells Provide Antitumor Protection
Defects in the Type I Interferon Pathway Contribute to Immunopathology in Herpetic Encephalitis
NF-κB Blockade Reduces the Severity of Herpetic Encephalitis in Mice with the IRF3 R278Q Mutation
Ketogenic Diet During Cancer Immunotherapy Boosts Interferon Production
Survival Increases from 42% to 67%
High-Dose Influenza Vaccine Reduces Risk of Cardiovascular Complications in Older Adults
Hospitalization Risk for Heart Failure Decreases by Nearly 20%
Itaconate Protects Against Inflammation in Atherosclerosis
Itaconate Reduces ROS Formation, Type I Interferon Production, and IL-1β Secretion
Physical Exercise After Colorectal Cancer Treatment Reduces Recurrence Risk by 28%
Possible Mechanism – Reduced Inflammation and Enhanced Immune Surveillance
Fumarate Enhances Interferon Production During Viral Infection
Fumarate Directly Activates MAVS – A Central Component of the Antiviral Signaling Pathway
Type I and Type III Interferons Disrupt Lung Repair After Viral Infection
Interferon-λ Impairs Lung Barrier Function via p53 Activation
mRNA IFN-I Nanoparticles Suppress Lung Metastases
A Candidate for Third-Generation Interferon-Based Cancer Therapy
NKp30 NK Cells Determine the Effectiveness of Peg-IFN-α2b Therapy in Chronic Hepatitis B
Why Interferon Therapy Is Not Effective for Everyone
How Aging Alters the Response to Coronavirus
STAT3-Dependent Processes – The Basis of Severe COVID-19 in the Elderly
Interferon-α Promotes Functional Cure of Chronic Hepatitis B by Inducing Liver Steatosis
Elevated Lipid Levels May Improve Response to Peg-IFN Therapy
SLIC-IFN-γ: Bacteria That Help Overcome Resistance to Cancer Immunotherapy
Targeted Delivery of Interferon-γ Enhances the Effect of PD-1 Blockade
Influenza and COVID-19 – Potential Triggers of Cancer Progression
Respiratory Viruses Elevate IL-6 Levels, Activating Dormant Breast Cancer Cells
Regulatory T Cells in Brown Adipose Tissue Support Thermogenesis by Suppressing Interferon-Gamma Production
Treg Protects Mitochondria and Prevents Metabolic Dysfunction
Interferon Gamma Reduces the Angiogenic Potential of Cancer Cells
IFN-γ Suppresses Perlecan Gene Expression and Tumor Growth
CD388 – A New Drug for the Treatment and Prevention of Influenza
The Drug Blocks Neuraminidase and Protects Against a Broad Range of Influenza A and B Viruses
SPENCD: A Rare Bone Disease Identified as an Interferonopathy
ACP5 Gene Mutations Lead to Excessive Interferon Pathway Activation
Type I Interferons Increase Gonococcal Survival
Interferon-Epsilon Promotes Gonorrhea Progression
Type I Interferons and T Cell Dysregulation in IBD
Endogenous IFN-β Controls Intestinal Inflammation
Interferons in Inflammatory Bowel Disease
The Protective and Damaging Roles of Interferons and Their Therapeutic Potential
Interferon-γ and Serotonin in Irritable Bowel Syndrome
Interferon-γ Increases Serotonin Availability, Disrupting Gut Motility
Why Bats Carry Viruses Without Getting Sick
Interferon Lambda Suppresses Marburg Virus
Type I Interferon Reduces Monkeypox Severity
Early Administration Maximizes Antiviral Effectiveness
Interferon-Gamma Against Leptomeningeal Metastases
For Antitumor Effect, IFNγ Requires NK Cells
Next-Generation Cancer and Virus Vaccines: The SABER Platform
SABER molecules enhance cross-presentation by improving antigen delivery to the endoplasmic reticulum
Β-Glucan Reprograms Immunity and Reduces Influenza Severity
Protective effect depends on type I interferon, Dectin-1, and T cells
PD-L1 Suppresses Interferon Response, Enhancing Oncolytic Virus Efficacy”
Combining oncolytic viruses with PD-1/PD-L1 blockers is a promising cancer treatment strategy
How to Protect a Newborn: Vaccination Before and After Birth
Antibody Transfer Before and After Delivery
Interferon-gamma suppresses the anti-tumor activity of T cells
Ablation of IFN-γ receptor on CD8+ T cells enhances tumor control
METTL3 Inhibitor Triggers Interferon Response, Enhancing Anti-Tumor Immunity
A combination of METTL3 inhibitor and anti-PD-1 improves cancer survival
Shingles vaccination reduces dementia risk by 20%
A natural experiment among residents of Wales